Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human

Alkylating agents are a key component of cancer chemotherapy. Several cellular mechanisms are known to be important for its survival, particularly DNA repair and xenobiotic detoxification, yet genomic screens indicate that additional cellular components may be involved. Elucidating these components...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zanotto-Filho, Alfeu, Dashnamoorthy, Ravi, Loranc, Eva, de Souza, Luis H. T., Moreira, José C. F., Suresh, Uthra, Chen, Yidong, Bishop, Alexander J. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839732/
https://ncbi.nlm.nih.gov/pubmed/27100653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153970
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