Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human

Alkylating agents are a key component of cancer chemotherapy. Several cellular mechanisms are known to be important for its survival, particularly DNA repair and xenobiotic detoxification, yet genomic screens indicate that additional cellular components may be involved. Elucidating these components...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Zanotto-Filho, Alfeu, Dashnamoorthy, Ravi, Loranc, Eva, de Souza, Luis H. T., Moreira, José C. F., Suresh, Uthra, Chen, Yidong, Bishop, Alexander J. R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839732/
https://ncbi.nlm.nih.gov/pubmed/27100653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153970
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