Mechanisms of acute toxicity in NKG2D Chimeric Antigen Receptor T cell treated mice()

Targeting cancer through the use of effector T cells bearing chimeric antigen receptors (CARs) leads to elimination of tumors in animals and patients, but recognition of normal cells or excessive activation can result in significant toxicity and even death. CAR T cells based on modified NKG2D recept...

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Pubblicato in:J Immunol
Autori principali: Sentman, Marie-Louise, Murad, Joana M., Cook, W. James, Wu, Ming-Ru, Reder, Jake, Baumeister, Susanne H., Dranoff, Glenn, Fanger, Michael W., Sentman, Charles L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136298/
https://ncbi.nlm.nih.gov/pubmed/27849169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600769
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