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Advances in the use of Natural Receptor- or Ligand-Based Chimeric Antigen Receptors (CARs) in haematologic malignancies

Chimeric antigen receptors (CAR)-T cell therapy has recently made promising advances towards treatment of B-cell malignancies. This approach makes use of an antibody-derived single chain variable fragment (scFv)-based CAR to target the CD19 antigen. Currently scFvs are the most common strategy for c...

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Bibliografische gegevens
Gepubliceerd in:Best Pract Res Clin Haematol
Hoofdauteurs: Murad, Joana M., Graber, David J., Sentman, Charles L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428197/
https://ncbi.nlm.nih.gov/pubmed/29909918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.beha.2018.03.003
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