Chimeric Antigen Receptor T Cells Targeting NKG2D-Ligands Show Robust Efficacy Against Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia

CAR T cell approaches to effectively target AML and T-ALL without off-tumor effects on healthy myeloid or T cell compartments respectively are an unmet medical need. NKG2D-ligands are a promising target given their absence on healthy cells and surface expression in a wide range of malignancies. NKG2...

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Опубликовано в: :Front Immunol
Главные авторы: Driouk, Lina, Gicobi, Joanina K., Kamihara, Yusuke, Rutherford, Kayleigh, Dranoff, Glenn, Ritz, Jerome, Baumeister, Susanne H. C.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769813/
https://ncbi.nlm.nih.gov/pubmed/33384686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.580328
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