Chimeric Antigen Receptor T Cells Targeting NKG2D-Ligands Show Robust Efficacy Against Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia

CAR T cell approaches to effectively target AML and T-ALL without off-tumor effects on healthy myeloid or T cell compartments respectively are an unmet medical need. NKG2D-ligands are a promising target given their absence on healthy cells and surface expression in a wide range of malignancies. NKG2...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Driouk, Lina, Gicobi, Joanina K., Kamihara, Yusuke, Rutherford, Kayleigh, Dranoff, Glenn, Ritz, Jerome, Baumeister, Susanne H. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769813/
https://ncbi.nlm.nih.gov/pubmed/33384686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.580328
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