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MICROMOLAR INTRACELLULAR HYDROGEN PEROXIDE DISRUPTS METABOLISM BY DAMAGING IRON-SULFUR ENZYMES

An Escherichia coli strain that cannot scavenge hydrogen peroxide has been used to identify the cell processes that are most sensitive to this oxidant. Low micromolar concentrations of H(2)O(2) completely blocked the biosynthesis of leucine. The defect was tracked to the inactivation of isopropylmal...

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Publicat a:J Biol Chem
Autors principals: Jang, Soojin, Imlay, James A
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136138/
https://ncbi.nlm.nih.gov/pubmed/17102132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M607646200
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