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MICROMOLAR INTRACELLULAR HYDROGEN PEROXIDE DISRUPTS METABOLISM BY DAMAGING IRON-SULFUR ENZYMES
An Escherichia coli strain that cannot scavenge hydrogen peroxide has been used to identify the cell processes that are most sensitive to this oxidant. Low micromolar concentrations of H(2)O(2) completely blocked the biosynthesis of leucine. The defect was tracked to the inactivation of isopropylmal...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5136138/ https://ncbi.nlm.nih.gov/pubmed/17102132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M607646200 |
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