FMN2 makes perinuclear actin to protect nuclei during confined migration and promote metastasis

Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus during migration in confined microenvironments. The formin-family actin filament nuc...

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Bibliographische Detailangaben
Veröffentlicht in:Cell
Hauptverfasser: Skau, Colleen T., Fischer, Robert S., Gurel, Pinar, Racine-Thiam, Hawa, Tubbs, Anthony, Baird, Michelle A., Davidson, Michael W., Piel, Matthieu, Alushin, Gregory M., Nussenzweig, Andre, Steeg, Patricia S., Waterman, Clare M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135586/
https://ncbi.nlm.nih.gov/pubmed/27839864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.10.023
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