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BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence

Fibrodysplasia ossificans progressiva (FOP) patients carry a missense mutation in ACVR1 [617G > A (R206H)] that leads to hyperactivation of BMP-SMAD signaling. Contrary to a previous study, here we show that FOP fibroblasts showed an increased efficiency of induced pluripotent stem cell (iPSC) ge...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Hayashi, Yohei, Hsiao, Edward C., Sami, Salma, Lancero, Mariselle, Schlieve, Christopher R., Nguyen, Trieu, Yano, Koyori, Nagahashi, Ayako, Ikeya, Makoto, Matsumoto, Yoshihisa, Nishimura, Ken, Fukuda, Aya, Hisatake, Koji, Tomoda, Kiichiro, Asaka, Isao, Toguchida, Junya, Conklin, Bruce R., Yamanaka, Shinya
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135304/
https://ncbi.nlm.nih.gov/pubmed/27794120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603668113
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