Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation

BACKGROUND: Abnormal activation of endochondral bone formation in soft tissues causes significant medical diseases associated with disability and pain. Hyperactive mutations in the bone morphogenetic protein (BMP) type 1 receptor ACVR1 lead to fibrodysplasia ossificans progressiva (FOP), a rare gene...

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Bibliografiske detaljer
Main Authors: Matsumoto, Yoshihisa, Hayashi, Yohei, Schlieve, Christopher R, Ikeya, Makoto, Kim, Hannah, Nguyen, Trieu D, Sami, Salma, Baba, Shiro, Barruet, Emilie, Nasu, Akira, Asaka, Isao, Otsuka, Takanobu, Yamanaka, Shinya, Conklin, Bruce R, Toguchida, Junya, Hsiao, Edward C
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892046/
https://ncbi.nlm.nih.gov/pubmed/24321451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-8-190
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