Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-dependent Deacetylation in Response to Membrane Depolarization

Mitochondrial sirtuins, SIRT3-5, are NAD(+)-dependent deacylases and ADP-ribosyltransferases critical for stress responses. However, a comprehensive understanding of sirtuin targets, regulation of sirtuin activity, and the relationships between sirtuins remains a key challenge in mitochondrial physi...

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Publicado en:Cell
Autores principales: Yang, Wen, Nagasawa, Koji, Münch, Christian, Xu, Yingjie, Satterstrom, Kyle, Jeong, Seungmin, Hayes, Sebastian D, Jedrychowski, Mark P., Vyas, F. Sejal, Zaganjor, Elma, Guarani, Virginia, Ringel, Alison E., Gygi, Steven P., Harper, J. Wade, Haigis, Marcia C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134900/
https://ncbi.nlm.nih.gov/pubmed/27881304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.10.016
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