Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

The PARKIN (PARK2) ubiquitin ligase and its regulatory kinase PINK1 (PARK6), often mutated in familial early onset Parkinson’s Disease (PD), play central roles in mitochondrial homeostasis and mitophagy.(1–3) While PARKIN is recruited to the mitochondrial outer membrane (MOM) upon depolarization via...

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Bibliografiset tiedot
Päätekijät: Sarraf, Shireen A., Raman, Malavika, Guarani-Pereira, Virginia, Sowa, Mathew E., Huttlin, Edward L., Gygi, Steven P., Harper, J. Wade
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641819/
https://ncbi.nlm.nih.gov/pubmed/23503661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12043
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