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QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology

The mitochondrial contact site and cristae junction (CJ) organizing system (MICOS) dynamically regulate mitochondrial membrane architecture. Through systematic proteomic analysis of human MICOS, we identified QIL1 (C19orf70) as a novel conserved MICOS subunit. QIL1 depletion disrupted CJ structure i...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Guarani, Virginia, McNeill, Elizabeth M, Paulo, Joao A, Huttlin, Edward L, Fröhlich, Florian, Gygi, Steven P, Van Vactor, David, Harper, J Wade
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439739/
https://ncbi.nlm.nih.gov/pubmed/25997101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06265
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