QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology

The mitochondrial contact site and cristae junction (CJ) organizing system (MICOS) dynamically regulate mitochondrial membrane architecture. Through systematic proteomic analysis of human MICOS, we identified QIL1 (C19orf70) as a novel conserved MICOS subunit. QIL1 depletion disrupted CJ structure i...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Guarani, Virginia, McNeill, Elizabeth M, Paulo, Joao A, Huttlin, Edward L, Fröhlich, Florian, Gygi, Steven P, Van Vactor, David, Harper, J Wade
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2015
Onderwerpen:
Cell Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4439739/
https://ncbi.nlm.nih.gov/pubmed/25997101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06265
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