Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition

Signal transducer and activator of transcription 3 (STAT3) has important roles in cancer aggressiveness and has been confirmed as an attractive target for cancer therapy. In this study, we used a dual-luciferase assay to identify that pectolinarigenin inhibited STAT3 activity. Further studies showed...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhang, Tao, Li, Suoyuan, Li, Jingjie, Yin, Fei, Hua, Yingqi, Wang, Zhouying, Lin, Binhui, Wang, Hongsheng, Zou, Dongqing, Zhou, Zifei, Xu, Jing, Yi, Chengqing, Cai, Zhengdong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133974/
https://ncbi.nlm.nih.gov/pubmed/27735939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.305
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