NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy

Combretastatin A-4 (CA-4), a tubulin-depolymerizing agent, shows promising antitumor efficacy and has been under several clinical trials in solid tumors for 10 years. Autophagy has an important pro-survival role in cancer therapy, thus targeting autophagy may improve the efficacy of antitumor agents...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Wang, Hongsheng, Li, Wen, Xu, Jing, Zhang, Tao, Zuo, Dongqing, Zhou, Zifei, Lin, Binhui, Wang, Gangyang, Wang, Zhuoying, Sun, Wei, Sun, Mengxiong, Chang, Shimin, Cai, Zhengdong, Hua, Yingqi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636982/
https://ncbi.nlm.nih.gov/pubmed/28906492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.438
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