Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental gene regulation in multicellular organisms. PRC1 and PRC2 modify chromatin by catalysing histone H2A lysine 119 ubiquitylation (H2AK119u1), and H3 lysine 27 methylation (H3K27me3), respectively. Reciprocal crosstalk...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Cooper, Sarah, Grijzenhout, Anne, Underwood, Elizabeth, Ancelin, Katia, Zhang, Tianyi, Nesterova, Tatyana B., Anil-Kirmizitas, Burcu, Bassett, Andrew, Kooistra, Susanne M., Agger, Karl, Helin, Kristian, Heard, Edith, Brockdorff, Neil
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133711/
https://ncbi.nlm.nih.gov/pubmed/27892467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13661
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