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Incorporation of protein binding effects into likelihood ratio test for exome sequencing data
Statistical association studies are an important tool in detecting novel disease genes. However, for sequencing data, association studies confront the challenge of low power because of relatively small data sample size and rare variants. Incorporating biological information that reflects disease mec...
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| Опубликовано в: : | BMC Proc |
|---|---|
| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5133515/ https://ncbi.nlm.nih.gov/pubmed/27980649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12919-016-0043-8 |
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