Reoptimization of intensity-modulated proton therapy plans based on linear energy transfer

PURPOSE: We describe a treatment plan optimization method for intensity-modulated proton therapy (IMPT) that avoids high values of linear energy transfer (LET) in critical structures located within or near the target volume, while limiting degradation of the best possible physical dose distribution....

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Bibliographic Details
Published in:Int J Radiat Oncol Biol Phys
Main Authors: Unkelbach, Jan, Botas, Pablo, Giantsoudi, Drosoula, Gorissen, Bram, Paganetti, Harald
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133459/
https://ncbi.nlm.nih.gov/pubmed/27869082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2016.08.038
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