Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion

Polymorphisms in the SLC30A8 gene, which encodes the ZnT8 zinc transporter, are associated with altered susceptibility to type 2 diabetes (T2D), and SLC30A8 haploinsufficiency is protective against the development of T2D in obese humans. SLC30A8 is predominantly expressed in pancreatic islet β-cells...

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Pubblicato in:Endocrinology
Autori principali: Syring, Kristen E., Boortz, Kayla A., Oeser, James K., Ustione, Alessandro, Platt, Kenneth A., Shadoan, Melanie K., McGuinness, Owen P., Piston, David W., Powell, David R., O'Brien, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2016
Soggetti:
Rapid Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133349/
https://ncbi.nlm.nih.gov/pubmed/27754787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1573
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