Fhit loss‐associated initiation and progression of neoplasia in vitro

The FHIT gene, encompassing an active common fragile site, FRA3B, is frequently silenced in preneoplasia and cancer, through gene rearrangement or methylation of regulatory sequences. Silencing of Fhit protein expression causes thymidine kinase 1 downregulation, resulting in dNTP imbalance, and spon...

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Bibliografische gegevens
Gepubliceerd in:Cancer Sci
Hoofdauteurs: Karras, Jenna R., Schrock, Morgan S., Batar, Bahadir, Zhang, Jie, La Perle, Krista, Druck, Teresa, Huebner, Kay
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132276/
https://ncbi.nlm.nih.gov/pubmed/27513973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13032
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