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Fhit loss‐associated initiation and progression of neoplasia in vitro
The FHIT gene, encompassing an active common fragile site, FRA3B, is frequently silenced in preneoplasia and cancer, through gene rearrangement or methylation of regulatory sequences. Silencing of Fhit protein expression causes thymidine kinase 1 downregulation, resulting in dNTP imbalance, and spon...
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| Publicado no: | Cancer Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5132276/ https://ncbi.nlm.nih.gov/pubmed/27513973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13032 |
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