Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster

Comparative transcriptional profiling of a ΔbldM mutant of Streptomyces venezuelae with its unmodified progenitor revealed that the expression of a cryptic biosynthetic gene cluster containing both type I and type III polyketide synthase genes is activated in the mutant. The 29.5 kb gene cluster, wh...

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Bibliographic Details
Published in:Chembiochem
Main Authors: Thanapipatsiri, Anyarat, Gomez‐Escribano, Juan Pablo, Song, Lijiang, Bibb, Maureen J., Al‐Bassam, Mahmoud, Chandra, Govind, Thamchaipenet, Arinthip, Challis, Gregory L., Bibb, Mervyn J.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132015/
https://ncbi.nlm.nih.gov/pubmed/27605017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600396
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