Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

There is a constant need for new and improved drugs to combat infectious diseases, cancer, and other major life-threatening conditions. The recent development of genomics-guided approaches for novel natural product discovery has stimulated renewed interest in the search for natural product-based dru...

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מידע ביבליוגרפי
Main Authors: Laureti, Luisa, Song, Lijiang, Huang, Sheng, Corre, Christophe, Leblond, Pierre, Challis, Gregory L., Aigle, Bertrand
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2011
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076887/
https://ncbi.nlm.nih.gov/pubmed/21444795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019077108
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