Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats

The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC) cause pain and neurogenic inflammation in humans a...

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Detalhes bibliográficos
Publicado no:Mol Pain
Main Authors: Lehto, Sonya G, Weyer, Andy D, Youngblood, Beth D, Zhang, Maosheng, Yin, Ruoyuan, Wang, Weiya, Teffera, Yohannes, Cooke, Melanie, Stucky, Cheryl L, Schenkel, Laurie, Geuns-Meyer, Stephanie, Moyer, Bryan D, Wild, Kenneth D, Gavva, Narender R
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131813/
https://ncbi.nlm.nih.gov/pubmed/27899696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806916677761
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