AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

TRPM8 has been implicated in pain and migraine based on dorsal root- and trigeminal ganglion-enriched expression, upregulation in preclinical models of pain, knockout mouse studies, and human genetics. Here, we evaluated the therapeutic potential in pain of AMG2850 ((R)-8-(4-(trifluoromethyl)phenyl)...

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Detalhes bibliográficos
Publicado no:Naunyn Schmiedebergs Arch Pharmacol
Main Authors: Lehto, Sonya G., Weyer, Andy D., Zhang, Maosheng, Youngblood, Beth D., Wang, Judy, Wang, Weiya, Kerstein, Patrick C., Davis, Carl, Wild, Kenneth D., Stucky, Cheryl L., Gavva, Narender R.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359714/
https://ncbi.nlm.nih.gov/pubmed/25662185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-015-1090-9
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