AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

TRPM8 has been implicated in pain and migraine based on dorsal root- and trigeminal ganglion-enriched expression, upregulation in preclinical models of pain, knockout mouse studies, and human genetics. Here, we evaluated the therapeutic potential in pain of AMG2850 ((R)-8-(4-(trifluoromethyl)phenyl)...

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Bibliografske podrobnosti
izdano v:Naunyn Schmiedebergs Arch Pharmacol
Main Authors: Lehto, Sonya G., Weyer, Andy D., Zhang, Maosheng, Youngblood, Beth D., Wang, Judy, Wang, Weiya, Kerstein, Patrick C., Davis, Carl, Wild, Kenneth D., Stucky, Cheryl L., Gavva, Narender R.
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2015
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359714/
https://ncbi.nlm.nih.gov/pubmed/25662185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-015-1090-9
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