AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

TRPM8 has been implicated in pain and migraine based on dorsal root- and trigeminal ganglion-enriched expression, upregulation in preclinical models of pain, knockout mouse studies, and human genetics. Here, we evaluated the therapeutic potential in pain of AMG2850 ((R)-8-(4-(trifluoromethyl)phenyl)...

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Pubblicato in:Naunyn Schmiedebergs Arch Pharmacol
Autori principali: Lehto, Sonya G., Weyer, Andy D., Zhang, Maosheng, Youngblood, Beth D., Wang, Judy, Wang, Weiya, Kerstein, Patrick C., Davis, Carl, Wild, Kenneth D., Stucky, Cheryl L., Gavva, Narender R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359714/
https://ncbi.nlm.nih.gov/pubmed/25662185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-015-1090-9
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