Pancreatic Inflammation Redirects Acinar to Beta Cell Reprogramming

Using a transgenic mouse model to express MafA, Pdx1, and Neurog3 (3TF) in a pancreatic acinar cell- and doxycycline-dependent manner, we discovered that the outcome of transcription factor-mediated acinar to β-like cellular reprogramming is dependent on both the magnitude of 3TF expression and on r...

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Udgivet i:Cell Rep
Main Authors: Clayton, Hannah W., Osipovich, Anna B., Stancill, Jennifer S., Schneider, Judsen D., Vianna, Pedro G., Shanks, Carolyn M., Yuan, Weiping, Gu, Guoqiang, Manduchi, Elisabetta, Stoeckert, Christian J., Magnuson, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131369/
https://ncbi.nlm.nih.gov/pubmed/27851966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.10.068
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