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Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells
Efforts to control mammalian gene expression with ligand-responsive riboswitches have been hindered by lack of a general method for generating efficient switches in mammalian systems. Here we describe a rational-design approach that enables rapid development of efficient cis-acting aptazyme riboswit...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5130294/ https://ncbi.nlm.nih.gov/pubmed/27805569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18858 |
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