Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency

Pain perception can become altered in individuals with eating disorders and obesity for reasons that have not been fully elucidated. We show that leptin deficiency in ob/ob mice, or leptin insensitivity in the arcuate nucleus of the hypothalamus in mice with high-fat diet (HFD)-induced obesity, are...

Full description

Saved in:
Bibliographic Details
Published in:Neuropsychopharmacology
Main Authors: Cristino, Luigia, Luongo, Livio, Imperatore, Roberta, Boccella, Serena, Becker, Thorsten, Morello, Giovanna, Piscitelli, Fabiana, Busetto, Giuseppe, Maione, Sabatino, Di Marzo, Vincenzo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130126/
https://ncbi.nlm.nih.gov/pubmed/26081302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.173
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items