Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency

Pain perception can become altered in individuals with eating disorders and obesity for reasons that have not been fully elucidated. We show that leptin deficiency in ob/ob mice, or leptin insensitivity in the arcuate nucleus of the hypothalamus in mice with high-fat diet (HFD)-induced obesity, are...

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Bibliografiske detaljer
Udgivet i:Neuropsychopharmacology
Main Authors: Cristino, Luigia, Luongo, Livio, Imperatore, Roberta, Boccella, Serena, Becker, Thorsten, Morello, Giovanna, Piscitelli, Fabiana, Busetto, Giuseppe, Maione, Sabatino, Di Marzo, Vincenzo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130126/
https://ncbi.nlm.nih.gov/pubmed/26081302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.173
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