Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency

Pain perception can become altered in individuals with eating disorders and obesity for reasons that have not been fully elucidated. We show that leptin deficiency in ob/ob mice, or leptin insensitivity in the arcuate nucleus of the hypothalamus in mice with high-fat diet (HFD)-induced obesity, are...

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Spremljeno u:
Bibliografski detalji
Izdano u:Neuropsychopharmacology
Glavni autori: Cristino, Luigia, Luongo, Livio, Imperatore, Roberta, Boccella, Serena, Becker, Thorsten, Morello, Giovanna, Piscitelli, Fabiana, Busetto, Giuseppe, Maione, Sabatino, Di Marzo, Vincenzo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130126/
https://ncbi.nlm.nih.gov/pubmed/26081302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.173
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