Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling

In the hypothalamic arcuate nucleus (ARC), proopiomelanocortin (POMC) neurons and the POMC-derived peptide α–melanocyte-stimulating hormone (α-MSH) promote satiety. POMC neurons receive orexin-A (OX-A)-expressing inputs and express both OX-A receptor type 1 (OX-1R) and cannabinoid receptor type 1 (C...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Morello, Giovanna, Imperatore, Roberta, Palomba, Letizia, Finelli, Carmine, Labruna, Giuseppe, Pasanisi, Fabrizio, Sacchetti, Lucia, Buono, Lorena, Piscitelli, Fabiana, Orlando, Pierangelo, Di Marzo, Vincenzo, Cristino, Luigia
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855580/
https://ncbi.nlm.nih.gov/pubmed/27071101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521304113
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