Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene

Phosphatase and tensin homolog (PTEN) is a major tumor suppressor and usually silenced via the deletion, insertion and mutation. We previously discovered its inactivation via aberrant CpG island methylation. Here, we provide further evidence that EBV latent membrane protein 1(LMP1) can induce a high...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Peng, Hong, Chen, Yuxiang, Gong, Pinggui, Cai, Longmei, Lyu, Xiaoming, Jiang, Qiang, Wang, Jianguo, Lu, Juan, Yao, Kaitai, Liu, Kunping, Li, Jinbang, Li, Xin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129989/
https://ncbi.nlm.nih.gov/pubmed/27223069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9474
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