Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene

Phosphatase and tensin homolog (PTEN) is a major tumor suppressor and usually silenced via the deletion, insertion and mutation. We previously discovered its inactivation via aberrant CpG island methylation. Here, we provide further evidence that EBV latent membrane protein 1(LMP1) can induce a high...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Peng, Hong, Chen, Yuxiang, Gong, Pinggui, Cai, Longmei, Lyu, Xiaoming, Jiang, Qiang, Wang, Jianguo, Lu, Juan, Yao, Kaitai, Liu, Kunping, Li, Jinbang, Li, Xin
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129989/
https://ncbi.nlm.nih.gov/pubmed/27223069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9474
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