Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene

Phosphatase and tensin homolog (PTEN) is a major tumor suppressor and usually silenced via the deletion, insertion and mutation. We previously discovered its inactivation via aberrant CpG island methylation. Here, we provide further evidence that EBV latent membrane protein 1(LMP1) can induce a high...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Peng, Hong, Chen, Yuxiang, Gong, Pinggui, Cai, Longmei, Lyu, Xiaoming, Jiang, Qiang, Wang, Jianguo, Lu, Juan, Yao, Kaitai, Liu, Kunping, Li, Jinbang, Li, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129989/
https://ncbi.nlm.nih.gov/pubmed/27223069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9474
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