Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin

We have recently demonstrated a critical role for progranulin in bladder cancer. Progranulin contributes, as an autocrine growth factor, to the transformed phenotype by modulating Akt-and MAPK-driven motility, invasion and anchorage-independent growth. Progranulin also induces F-actin remodeling by...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Buraschi, Simone, Xu, Shi-Qiong, Stefanello, Manuela, Moskalev, Igor, Morcavallo, Alaide, Genua, Marco, Tanimoto, Ryuta, Birbe, Ruth, Peiper, Stephen C., Gomella, Leonard G., Belfiore, Antonino, Black, Peter C., Iozzo, Renato V., Morrione, Andrea
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129986/
https://ncbi.nlm.nih.gov/pubmed/27220888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9556
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