Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance

Lysine demethylase 5A (KDM5A/RBP2/JARID1A) is a histone lysine demethylase that is overexpressed in several human cancers including lung, gastric, breast and liver cancers. It plays key roles in important cancer processes including tumorigenesis, metastasis, and drug tolerance, making it a potential...

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Vydáno v:Oncotarget
Hlavní autoři: Gale, Molly, Sayegh, Joyce, Cao, Jian, Norcia, Michael, Gareiss, Peter, Hoyer, Denton, Merkel, Jane S., Yan, Qin
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129982/
https://ncbi.nlm.nih.gov/pubmed/27224921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9539
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