Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen

JARID1B (also known as KDM5B or PLU1) is a member of the JARID1 family of histone lysine demethylases responsible for the demethylation of trimethylated lysine 27 in histone H3 (H3K4me3), a mark for actively transcribed genes. JARID1B is overexpressed in several cancers, including breast cancer, pro...

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Bibliografiske detaljer
Main Authors: Sayegh, Joyce, Cao, Jian, Zou, Mike Ran, Morales, Alfonso, Blair, Lauren P., Norcia, Michael, Hoyer, Denton, Tackett, Alan J., Merkel, Jane S., Yan, Qin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3611010/
https://ncbi.nlm.nih.gov/pubmed/23408432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.419861
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