Gastric Lgr5(+) stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice

The cellular origin of gastric cancer remains elusive. Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is the first identified marker of gastric stem cells. However, the role of Lgr5(+) stem cells in driving malignant gastric cancer is not fully validated. Here, we deleted Smad4 a...

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Bibliografiska uppgifter
I publikationen:Cell Res
Huvudupphovsmän: Li, Xiu-Bin, Yang, Guan, Zhu, Liang, Tang, Yu-Ling, Zhang, Chong, Ju, Zhenyu, Yang, Xiao, Teng, Yan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
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Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129876/
https://ncbi.nlm.nih.gov/pubmed/27091432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.47
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