Efficient generation of selection‐gene‐free rat knockout models by homologous recombination in ES cells

Embryonic stem cell (ES cell)‐based rat knockout technology, although successfully developed in 2010, has seen very limited usage to date due to low targeting efficiency and a lack of optimized procedures. In this study, we performed gene targeting in ES cells from the Sprague–Dawley (SD) and the Fi...

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Bibliografiske detaljer
Udgivet i:FEBS Lett
Main Authors: Lan, He, Li, Shuping, Guo, Zihang, Men, Hongsheng, Wu, Yuanyuan, Li, Ning, Bryda, Elizabeth C., Capecchi, Mario R., Wu, Sen
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Research Letters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129459/
https://ncbi.nlm.nih.gov/pubmed/27597178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12388
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