Efficient generation of selection‐gene‐free rat knockout models by homologous recombination in ES cells

Embryonic stem cell (ES cell)‐based rat knockout technology, although successfully developed in 2010, has seen very limited usage to date due to low targeting efficiency and a lack of optimized procedures. In this study, we performed gene targeting in ES cells from the Sprague–Dawley (SD) and the Fi...

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Dades bibliogràfiques
Publicat a:FEBS Lett
Autors principals: Lan, He, Li, Shuping, Guo, Zihang, Men, Hongsheng, Wu, Yuanyuan, Li, Ning, Bryda, Elizabeth C., Capecchi, Mario R., Wu, Sen
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Research Letters
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129459/
https://ncbi.nlm.nih.gov/pubmed/27597178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12388
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