Glucocorticoid receptor and Histone deacetylase 6 mediate the differential effect of dexamethasone during osteogenesis of mesenchymal stromal cells (MSCs)

Lineage commitment and differentiation of mesenchymal stromal cells (MSCs) into osteoblasts in vitro is enhanced by a potent synthetic form of glucocorticoid (GC), dexamethasone (Dex). Paradoxically, when used chronically in patients, GCs exert negative effects on bone, a phenomenon known as glucoco...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rimando, Marilyn G., Wu, Hao-Hsiang, Liu, Yu-An, Lee, Chien-Wei, Kuo, Shu-Wen, Lo, Yin-Ping, Tseng, Kuo-Fung, Liu, Yi-Shiuan, Lee, Oscar Kuang-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5128810/
https://ncbi.nlm.nih.gov/pubmed/27901049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37371
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