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Isoflurane Exposure Induces Cell Death, Microglial Activation and Modifies the Expression of Genes Supporting Neurodevelopment and Cognitive Function in the Male Newborn Piglet Brain

Exposure of the brain to general anesthesia during early infancy may adversely affect its neural and cognitive development. The mechanisms mediating this are complex, incompletely understood and may be sexually dimorphic, but include developmentally inappropriate apoptosis, inflammation and a disrup...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Broad, Kevin D., Hassell, Jane, Fleiss, Bobbi, Kawano, Go, Ezzati, Mojgan, Rocha-Ferreira, Eridan, Hristova, Mariya, Bennett, Kate, Fierens, Igor, Burnett, Ryan, Chaban, Badr, Alonso-Alconada, Daniel, Oliver-Taylor, Aaron, Tachsidis, Ilias, Rostami, Jamshid, Gressens, Pierre, Sanders, Robert D., Robertson, Nicola J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127656/
https://ncbi.nlm.nih.gov/pubmed/27898690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166784
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