Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

HIV-1 vaccine design is informed by structural studies elucidating mechanisms by which broadly neutralizing antibodies (bNAbs) recognize and/or accommodate N-glycans on the trimeric envelope glycoprotein (Env). Variability in high-mannose and complex-type Env glycoforms leads to heterogeneity that u...

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Gepubliceerd in:Nat Struct Mol Biol
Hoofdauteurs: Gristick, Harry B, von Boehmer, Lotta, West, Anthony P, Schamber, Michael, Gazumyan, Anna, Golijanin, Jovana, Seaman, Michael S, Fätkenheuer, Gerd, Klein, Florian, Nussenzweig, Michel C, Bjorkman, Pamela J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127623/
https://ncbi.nlm.nih.gov/pubmed/27617431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3291
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