Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked UBQLN2 mutations

Missense mutations in ubiquilin 2 (UBQLN2) cause ALS with frontotemporal dementia (ALS–FTD). Animal models of ALS are useful for understanding the mechanisms of pathogenesis and for preclinical investigations. However, previous rodent models carrying UBQLN2 mutations failed to manifest any sign of m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Le, Nhat T. T., Chang, Lydia, Kovlyagina, Irina, Georgiou, Polymnia, Safren, Nathaniel, Braunstein, Kerstin E., Kvarta, Mark D., Van Dyke, Adam M., LeGates, Tara A., Philips, Thomas, Morrison, Brett M., Thompson, Scott M., Puche, Adam C., Gould, Todd D., Rothstein, Jeffrey D., Wong, Philip C., Monteiro, Mervyn J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127348/
https://ncbi.nlm.nih.gov/pubmed/27834214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608432113
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