Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABA(A) Receptors

Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment for depression, but SSRIs are effective in only half of the patients and typically take several weeks to relieve symptoms. The NMDA receptor antagonist ketamine exerts a rapid antidepressant action, but has tro...

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Bibliografiske detaljer
Udgivet i:Neuropsychopharmacology
Main Authors: Fischell, Jonathan, Van Dyke, Adam M, Kvarta, Mark D, LeGates, Tara A, Thompson, Scott M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569955/
https://ncbi.nlm.nih.gov/pubmed/25900119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.112
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