Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABA(A) Receptors

Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment for depression, but SSRIs are effective in only half of the patients and typically take several weeks to relieve symptoms. The NMDA receptor antagonist ketamine exerts a rapid antidepressant action, but has tro...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Fischell, Jonathan, Van Dyke, Adam M, Kvarta, Mark D, LeGates, Tara A, Thompson, Scott M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569955/
https://ncbi.nlm.nih.gov/pubmed/25900119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.112
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