Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABA(A) Receptors

Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment for depression, but SSRIs are effective in only half of the patients and typically take several weeks to relieve symptoms. The NMDA receptor antagonist ketamine exerts a rapid antidepressant action, but has tro...

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Bibliografische gegevens
Gepubliceerd in:Neuropsychopharmacology
Hoofdauteurs: Fischell, Jonathan, Van Dyke, Adam M, Kvarta, Mark D, LeGates, Tara A, Thompson, Scott M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569955/
https://ncbi.nlm.nih.gov/pubmed/25900119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.112
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