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Synthesis and Assay of SIRT1-Activating Compounds

The NAD(+)-dependent deacetylase SIRT1 plays key roles in numerous cellular processes including DNA repair, gene transcription, cell differentiation, and metabolism. Over-expression of SIRT1 protects against a number of age-related diseases including diabetes, cancer, and Alzheimer's disease. M...

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Bibliographic Details
Published in:Methods Enzymol
Main Authors: Dai, H., Ellis, J.L., Sinclair, D.A., Hubbard, B.P.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127272/
https://ncbi.nlm.nih.gov/pubmed/27423864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2016.01.012
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