Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer’s disease

In the mitochondria-mediated vicious cycle of Alzheimer’s disease (AD), intracellular amyloid β (Aβ) induces mitochondrial dysfunction and reactive oxygen species, which further accelerate Aβ accumulation. This vicious cycle is thought to play a pivotal role in the development of AD, although the mo...

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Udgivet i:Sci Rep
Main Authors: Oka, Sugako, Leon, Julio, Sakumi, Kunihiko, Ide, Tomomi, Kang, Dongchon, LaFerla, Frank M., Nakabeppu, Yusaku
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126576/
https://ncbi.nlm.nih.gov/pubmed/27897204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37889
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