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Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs

Melanoma brain metastases (MBM) occur in 10% to 50% of melanoma patients. They are often associated with a high morbidity and despite the improvements in the treatment of advanced melanoma, including immunotherapy, patients with MBM still have a poor prognosis. Antiangiogenic treatment was shown to...

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Bibliografske podrobnosti
izdano v:Am J Cancer Res
Main Authors: Du Four, Stephanie, Maenhout, Sarah K, Niclou, Simone P, Thielemans, Kris, Neyns, Bart, Aerts, Joeri L
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126270/
https://ncbi.nlm.nih.gov/pubmed/27904768
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