Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model

Melanoma patients are at a high risk of developing brain metastases, which are strongly vascularized and therefore have a significant risk of spontaneous bleeding. VEGF not only plays a role in neo-angiogenesis but also in the antitumor immune response. VEGFR-targeted therapy might not only have an...

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Sparad:
Bibliografiska uppgifter
I publikationen:Oncoimmunology
Huvudupphovsmän: Du Four, Stephanie, Maenhout, Sarah K., De Pierre, Kari, Renmans, Dries, Niclou, Simone P, Thielemans, Kris, Neyns, Bart, Aerts, Joeri L
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2015
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485747/
https://ncbi.nlm.nih.gov/pubmed/26137411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2014.998107
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